The effect of long-chain polyunsaturated ω-3 fatty acids on the arterial stiffness parameters in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy
Abstract
OBJECTIVE: To analyze the effect of long-chain (LC) polyunsaturated w-3 fatty acids (PUFAs) on the daily arterial stiffness parameters in patients with type 2 diabetes (DM2) and cardiovascular autonomic neuropathy (CAN).
MATERIAL AND METHODS: The study involved 39 patients with DM2 and verified functional stage of CAN. Patients were divided into 2 groups: therapy group (n=21) and control group (n=18). Patients of the control group received traditional hypoglycemic therapy; patients of the therapy group additionally received 1 capsule/day of the ω-3 PUFAs for three months.
RESULTS: The use of the ω-3 PUFAs resulted in a statistically significant decrease in aortic augmentation index (AAI) and pulse wave velocity in the aorta (PWV) during the active period. There was a decrease in AAI in the aorta and the brachial artery and in PWV in the aorta during the night.
CONCLUSION: The efficacy of ω-3-PUFAs is a result of a direct effect of the pharmacological agent on the circadian arterial stiffness parameters.
Цель исследования - провести анализ влияния препарата длинноцепочечных ω-3 полиненасыщенных высших жирных кислот на параметры суточного мониторинга ригидности артерий у больных сахарным диабетом 2-го типа с диабетической кардиоваскулярной автономной нейропатией. Материал и методы. Обследовали 39 больных сахарным диабетом 2-го типа с верифицированной функциональной стадией кардиоваскулярной автономной нейропатии. Пациентов распределили в две группы: основную (21 больной) и…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 39 participants or records.
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