Benefits of an anti-inflammatory diet compared to a low-residue diet during concurrent chemoradiation therapy for patients with locally advanced cervical cancer: a randomized clinical trial
Abstract
Background: Gastrointestinal (GI) toxicity frequently occurs in patients with locally advanced cervical cancer receiving concurrent chemoradiotherapy, often resulting in severe malnutrition.
Purpose: This study compared the effects of an anti-inflammatory diet (AID) versus a low-residue diet (LRD) on nutritional status, toxicity, inflammation, and treatment outcomes in women with locally advanced cervical cancer (LACC) undergoing chemoradiotherapy (CRT).
Methods: In this randomized controlled trial, women with LACC were assigned to either the AID or the LRD. Nutritional status, GI toxicity, inflammation, and tumor response were assessed at five time points, before, during, and after treatment.
Results: A total of 83 participants completed the study: 41 in the AID group and 42 in the LRD group. The AID group consumed more anti-inflammatory nutrients, and both groups showed nutritional recovery by visit 5, as indicated by Patient-Generated Subjective Global Assessment (PG-SGA) scores and lower rates of undernutrition. Although both groups experienced peak toxicity mid-treatment, the AID group reported fewer persistent GI symptoms by the end, consistent with more stable intestinal inflammation, as evidenced by calprotectin levels. Cytokine analysis showed lower IL-1β and IL-17A levels in the AID group at the final visit. A complete response to treatment was seen in 70.7% of the AID group versus 54.8% in the LRD group (p = 0.133). Overall survival rates were more favorable in…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 83 participants or records.
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