Enhancing Quality of Life and Emotional Well-Being in Atopic Dermatitis Patients: Clinical Evidence of a Dermocosmetic Lipid-Replenishing Regimen
Abstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by impaired skin barrier function, xerosis, and pruritus, significantly affecting quality of life (QoL). Effective dermocosmetic strategies are needed to alleviate symptoms and improve well-being.
Aims: This study assessed the efficacy of a lipid-replenishing dermocosmetic regimen, including a cleansing oil and emollient balm (Topicrem, Laboratoires NIGY, France), in adults with moderate to severe AD.
Patients/methods: A 4-week clinical study was conducted under dermatological supervision on 21 adults with moderate to severe AD. Patients applied the DA PROTECT Replenishing Cleansing Oil and Emollient Balm (Topicrem) once or twice daily. Efficacy was evaluated via TransEpidermal Water Loss (TEWL), corneometry, SCORAD (SCORing Atopic Dermatitis) index, and patient-reported outcomes. The impact on QoL was assessed using the Dermatology Life Quality Index (DLQI).
Results: After 4 weeks, TEWL decreased by 27%, and skin hydration increased by 89% indicating a reinforced skin barrier and improved moisturization. The SCORAD index improved by 27%, pruritus decreased by 61%, and sleep quality improved by 62%, reflecting reduced disease severity. The DLQI score improved by 68%, demonstrating a strong correlation between the dermocosmetic regimen and enhanced QoL, particularly in items related to symptoms, sleep, social life, and emotional well-being. Patient satisfaction was high, with 81% rating…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 21 participants or records.
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