Self-Reported Changes in Premenstrual and Menstrual Symptoms among Females Taking a Novel Multinutrient Supplement: A Pilot Study
Abstract
Background: Premenstrual and menstrual symptoms arise in response to cyclical hormonal fluctuations and encompass psychological and physical manifestations that may significantly impair quality of life. Treatment options are limited, demonstrate inconsistent efficacy, and are associated with notable adverse effects. There is growing interest in evidence-based nutritional approaches, with several placebo-controlled trials demonstrating that certain nutrient supplements significantly alleviate menstrual-cycle-related symptomatology.
Objectives: This single-arm pilot study aims to evaluate self-reported changes in premenstrual and menstrual symptoms in females taking a novel multinutrient supplement containing saffron extract, chamomile extract, essential minerals (chromium, magnesium, zinc, iron), vitamins (D, B6, C), and- omega-3 (n-3) fatty acids, using advanced encapsulation technology.
Methods: Forty females (mean age: 33 y) with premenstrual and menstrual symptoms consumed the supplement daily for 3 consecutive menstrual cycles. The validated Menstrual Symptom Questionnaire (MSQ) and a 5-point severity rating scale evaluated symptoms at baseline and after each menstrual cycle.
Results: Overall MSQ scores decreased significantly from baseline to cycle 1 (P = 0.0028), cycle 2 (P P P P < 0.0001). By cycle 3, 88% of participants agreed that the supplement reduced symptom severity, and 82% agreed that the supplement reduced symptom duration.
Conclusions: These findings suggest…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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