Lifestyle multidomain intervention, omega-3 supplementation, or both for reducing the risk of developing clinically relevant depressive symptoms in older adults with memory complaints? Secondary analysis from the MAPT trial
Abstract
Background: We tested the associations of a lifestyle multidomain intervention (MI), omega‐3 supplementation (O3) or their combination with the change of clinically meaningful depressive symptoms in older adults. Methods: Secondary analysis of the 3‐year Multidomain Alzheimer Preventive Trial (MAPT), in which 1679 people, ≥70 years with memory complaints were randomized into: MI, O3, MI + O3, or placebo. MI was composed of nutritional and physical activity counselling and cognitive training. O3 supplementation corresponded to a daily dose of 1000 mg of omega‐3. Discrete‐time cox regressions were performed for each outcome. Three binary variables of incidence of depressive symptoms were created from the 15‐item geriatric depression scale (GDS‐15): minimum clinically meaningful depressive symptoms (≥2‐point increase in GDS‐15), moderate depressive symptoms (GDS‐15 ≥ 5), and severe depressive symptoms (GDS‐15 ≥ 10) DS. Results: Discrete‐time cox proportional hazards have found no associations for all of the analysis. The incidence of severe depressive symptoms across groups were, respectively: 1.1, 2.4, 2.3 and 2.5 per 100 person year for MI + O3, for O3, for MI, for placebo. There was a trend for a decreased risk of developing severe DS compared to placebo in the MI + O3 group (p = 0.085 after adjustment). Conclusions: To conclude, we did not find any association of a lifestyle multidomain intervention with the onset of clinically depressive symptoms in older adults with…
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 1,679 participants or records.
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