The impact of aging on outcomes in acute respiratory distress syndrome: a multicenter cohort study
Abstract
Advanced age significantly influences outcomes in acute respiratory distress syndrome, with implications for intensive care unit-free days, ventilator-free days, and mortality. Understanding these relationships is essential for optimizing care in elderly populations. This retrospective multicenter cohort study included 1992 patients with acute respiratory distress syndrome from the Acute Respiratory Distress Syndrome Network trials, specifically the ALTA (Albuterol for the Treatment of Acute Lung Injury), EDEN (Early vs. Delayed Enteral Nutrition), Omega (Omega-3 Fatty Acid, Gamma-Linolenic Acid, and Anti-Oxidant Supplementation), and SAILS (Statins for Acutely Injured Lungs from Sepsis) studies, categorized into four age groups: 80 years (n = 91, 4.6%). Key demographic characteristics, including gender, race, and ethnicity, were analyzed. Regression models adjusted for driving pressure and PaO₂/FiO₂ ratio examined associations between age and intensive care unit-free days, ventilator-free days, and mortality at 60 and 90 days. The results showed that older age was correlated with significantly fewer intensive care unit-free days and ventilator-free days and higher mortality. Patients > 80 years experienced 8.47 fewer intensive care unit-free days (95% CI: –11.24 to –5.69) and 9.26 fewer ventilator-free days (95% CI: –12.22 to –6.31) compared to those 80 years. Results persisted at 90 days. Subgroup analysis revealed demographic disparities: non-Hispanic White patients…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 915 participants or records.
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