Dose–response relationship of dietary Omega-3 fatty acids on slowing phenotypic age acceleration: a cross-sectional study
Abstract
Purpose This study investigates the association between dietary Omega-3 fatty acid intake and accelerated phenotypic aging, referred to as PhenoAgeAccel. PhenoAgeAccel is defined as the difference between phenotypic biological age, calculated using blood biochemical markers, and chronological age. This study assesses the potential of Omega-3 intake to slow biological aging and its implications for public health. Methods Utilizing data from the NHANES from 1999 to 2018, this cross-sectional study included 20,337 adult participants. Through a nationally representative sample combined with comprehensive phenotypic age calculation methods, a cross-sectional analysis of Omega-3 fatty acid intake and accelerated phenotypic aging was conducted. Weighted generalized linear regression models and restricted cubic spline analyses were applied to explore the potential non-linear relationships between them. Threshold effects were further clarified through piecewise regression models, and the impact of different demographic and health characteristics was evaluated through interaction effect tests. Results After adjusting for various potential confounding factors, a significant negative correlation was found between Omega-3 fatty acid intake and PhenoAgeAccel (β = −0.071; 95% CI: −0.119, −0.024; p = 0.004), indicating that an increase in Omega-3 intake is associated with a slowdown in PhenoAgeAccel. Specifically, for each unit increase in Omega-3 intake, the accelerated phenotypic aging…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 20,337 participants or records.
Read the paper
Related studies
- Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review
- Effects of omega-3 polyunsaturated fatty acid intake in patients with chronic kidney disease: Systematic review and meta-analysis of randomized controlled trials
- Effect of omega-3 fatty acids on cognition: an updated systematic review of randomized clinical trials
- The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: A narrative review
- Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review
- Omega-3 fatty acid nanocarriers: Characterization and potential applications
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.