Effect of Omega-3 Fatty Acid Supplementation on Cellular Lipid Profile: A Case Series
Abstract
Objective
The purpose of this report is to describe changes in the cellular lipid profile of participants following 120 days of omega-3 fatty acid supplementation.
Methods
Six participants received a non-gastric acid-resistant omega-3 fatty acid supplement, with dosages personalized based on preintervention red blood cell (RBC) omega-6 to omega-3 ratios. Blood samples were analyzed pre- and postintervention to determine changes in RBC lipid profiles.
Results
Six participants who were either fully or partially compliant with the supplementation showed a mean reduction of 41.2% in their RBC omega-6 to omega-3 ratio, with 2 participants achieving a ratio of 4:1 or lower.
Conclusion
Several of the compliant participants with Omega-3 fatty acid supplementation recorded a reduction in the omega-6 to omega-3 ratio in RBC lipid profiles.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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