Hypomanic symptoms and first manic episode during ketogenic diet treatment in a patient taking venlafaxine: a case report with longitudinal glucose-ketone index and clinical monitoring
Abstract
Background: The ketogenic diet (KD) is gaining increasing interest as a metabolic intervention for neuropsychiatric disorders, including mood disorders. However, its potential role in clinically relevant affective changes, such as hypomania or mania, remains insufficiently characterized.
Methods: We present the case of a woman with a previous history of major depressive episode with psychotic symptoms and a posterior history of recurrent episodes of mild depression, who never achieved complete symptom remission. In an effort to ameliorate her chronic depressive symptoms, the patient started a KD for approximately 6 months. Metabolic monitoring included daily capillary measurements of glucose and ketone levels, with calculation of the glucose-ketone index (GKI) to assess ketosis and dietary adherence. Anthropometric parameters and physiological variables were recorded longitudinally. Laboratory assessments were performed before, during, and after the intervention. Psychiatric outcomes were evaluated using clinical scales, including the YMRS, PANSS, CGI, GAF, WHODAS and OAS, allowing assessment of symptom severity and clinical evolution. Pharmacologic, dietary, substance-related, sleep-related, and psychosocial exposures were reconstructed across clinically relevant phases.
Results: After KD initiation, the patient reported improved mood and vitality, increased energy, reduced need for sleep, slight euphoria, and increased goal-directed activity. This period was…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.