Detection of reduced dopamine transporter availability by 123I‐N‐omega‐fluoropropyl‐2‐beta‐carbomethoxy‐3‐beta (4‐iodophenyl) nortropane single‐photon emission computed tomography in a patient of frontotemporal dementia with motor neuron disease
Abstract
I-N-omega-fluoropropyl-2-beta-carbomethoxy3-beta (4-iodophenyl) nortropane (I-FP-CIT) singlephoton emission computed tomography (SPECT) is used to detect abnormal dopamine transporter density, which reflects nigrostriatal degeneration. Although I-FP-CIT uptake reduction has been observed in 30% of patients with frontotemporal dementia (FTD), a clinical syndrome with a heterogeneous molecular basis, no previous studies have examined I-FP-CIT uptake in homogeneous FTD based on neuropathology. Severe degeneration of nigrostriatal neurons in FTD with motor neuron disease (MND; FTD-MND), a uniform neuropathology, has been shown in autopsy series ; however, IFP-CIT SPECT has never been used to detect FTD-MND. Here, we report the case of a patient with FTD-MND who showed I-FP-CIT uptake reduction on SPECT. The patient was a right-handed Japanese woman who was 65 years old at the time of presentation at our hospital. The patient’s family provided written consent for the publication of this report. Her medical history and family history were unremarkable. She had graduated from high school at the age of 18 and was a housewife. At the age of 63, she started displaying obsessive behaviours such as frequently checking her closet for thieves and quickly turning off the heating system for fear of fire. At 65 years old, she was admitted to our hospital. She repeated stereotypical, worrisome phrases such as ‘I’m finished, I want to die’ and ‘My house is on fire’. The patient was extremely…
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.