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Premature Acute Myocardial Infarction in a Competitive Athlete: Exploring the Potential Impact of Omega-3/Omega-6 Ratio

Chiara BM, Alessandra P, Filippo L, Calchera I, Simone T, Matteo P, Maddalena L, Pietro V et al.

JACC. Case reports, 2026

Abstract

Background: Acute myocardial infarction is increasing in younger adults. Epidemiologic studies suggest a low Omega-3/Omega-6 ratio may contribute to cardiac events. Athletes on a Western diet and high training loads have reduced Omega-3/Omega-6 ratios.

Case summary: A 29-year-old man with an unremarkable medical history experienced cardiac arrest during a soccer match. Coronary angiography revealed an atherosclerotic plaque occluding the proximal left anterior descending artery, treated with 2 drug-eluting stents. The patient was admitted to intensive care; brain death was declared the next day. No cardiovascular risk factors were identified, except for a reduced Omega-3/Omega-6 ratio.

Discussion: A young athlete without classical risk factors but with a low Omega-3/Omega-6 ratio developed unstable coronary disease. This association warrants further investigation.

Take-home messages: This case highlights the potential role of Omega-3/Omega-6 ratios in cardiovascular risk in young athletes and underscores the importance of performing immediate cardiopulmonary resuscitation before advanced medical services arrive.

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