A 35-Year-Old Woman With Recurrent Hypertriglyceridemia-Induced Pancreatitis in Pregnancy Managed With Fenofibrate and Plasmapheresis
Abstract
BACKGROUND Hypertriglyceridemia-induced pancreatitis in pregnancy is a rare condition that requires emergency management to prevent maternal morbidity and fetal loss. Physiological lipid shifts during pregnancy can severely exacerbate underlying dyslipidemia, leading to an increase in triglyceride levels >11.3 mmol/L, which can trigger acute pancreatitis, which requires rapid lipid lowering. This report describes the case of a 35-year-old woman with recurrent hypertriglyceridemia-induced pancreatitis in pregnancy managed with fenofibrate and therapeutic plasma exchange (TPE), resulting in successful delivery at 36 weeks. CASE REPORT A 35-year-old pregnant woman presented at 22 weeks of gestation with acute abdominal pain. Laboratory tests revealed a triglyceride level of 29.57 mmol/L, leading to the diagnosis of hypertriglyceridemia-induced pancreatitis in pregnancy following the careful exclusion of other common etiologies. She was initially treated with fasting, fluid resuscitation, and TPE, which successfully lowered her triglyceride levels. However, she experienced a recurrence at 25 weeks of gestation. A second TPE was performed, followed by the initiation of oral fenofibrate (200 mg/day) for maintenance therapy due to triglyceride rebound. This sustained regimen maintained her triglyceride levels safely below 13 mmol/L. She successfully delivered a healthy male infant at 36 weeks via cesarean section. CONCLUSIONS This report highlights the presentation, diagnosis, and…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.