Remission of severe familial proteinuria in a Bracco Italiano dog
Abstract
The objective of this report was to document clinical remission of suspected familial proteinuria in a Bracco Italiano dog. A 4-year-old intact female Bracco Italiano with a familial history of amyloidosis was presented because of unilateral chemosis, polyuria, and polydipsia. Hypoalbuminemia and severe proteinuria were detected via initial diagnostics. Although no renal histopathologic assessment was done, there was a strong clinical suspicion for renal amyloidosis. The dog was treated with telmisartan and colchicine (in addition to other therapies) for proteinuria and achieved clinical remission > 5 y post-diagnosis. Key clinical message: Telmisartan is an appropriate 1st-line therapy for proteinuric dogs. Favorable long-term outcomes are possible for dogs with severe proteinuria. Prospective studies are warranted to evaluate effects of telmisartan on AA amyloidogenesis.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.