Cardiorespiratory fitness, muscular strength, balance and tumor biomarker dynamics following a multimodal exercise-nutrition intervention in a multimorbid elderly colorectal cancer survivor with liver metastasis: a case report
Abstract
Background: Older survivors of metastatic colorectal cancer frequently present with multimorbidity, functional impairment, and limited evidence-based guidance for non-pharmacological treatment. This case report describes a complex geriatric colorectal cancer survivor with a history of liver metastasis and significant comorbidity who underwent a supervised multimodal exercise-nutrition intervention.
Case description: A 78-year-old colorectal cancer survivor with previous hepatic metastasis completed an 8-week supervised concurrent exercise and nutritional intervention. The intervention program primarily combined aerobic, resistance, and balance training with a Mediterranean- and Nordic-style diet emphasizing anti-inflammatory and antioxidant foods. Outcomes included anthropometry, cardiorespiratory performance via a 6-minute walk test with gas analysis, lower-limb strength (sit-to-stand test), postural balance on a force platform, and tumor biomarkers [carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9)]. Functional outcomes demonstrated marked improvements: walking distance during the six-minute walk test increased by 52%, oxygen uptake during the 6MWT by 50%, and lower-limb strength by 33%. Balance assessments revealed significant reductions in sway area (-35.6% eyes open; -51.8% eyes closed), indicating improved postural stability. These physiological adaptations were accompanied by modest reductions in body weight (-4.3%) and resting heart rate (-10.8%).…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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