Wheat-dependent exercise-induced anaphylaxis: The diagnostic utility of Omega-5 Gliadin in two clinical cases from Lima, Peru
Abstract
BACKGROUND
Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare, potentially life-threatening condition triggered by wheat ingestion followed by physical activity.
CASE REPORT
This report describes two cases of young individuals in Lima, Peru, diagnosed with WDEIA. The diagnosis was confirmed through skin prick testing and the Allergy Explorer2 (ALEX-2) microarray, identifying omega-5gliadin (Tria19) as the main allergen. Both patients experienced episodes of anaphylaxis, one of which required adrenaline administration.
CONCLUSION
The importance of molecular diagnostics to confirm WDEIA is highlighted, and preventive strategies such as avoiding wheat before exercise and emergency plans are discussed. These cases underscore the need for greater clinical awareness and improved access to life-saving interventions in resource-limited regions.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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