Efficacy and Nephrotoxicity of Extended versus Intermittent Infusion of Beta-Lactams for the Treatment of Ventilator Associated Pneumonia
Abstract
Patients in the intensive care unit (ICU) are at risk for dying not only from their critical illness but also from secondary processes such as nosocomial infection. Pneumonia is the second most common nosocomial infection in critically ill patients. Eighty-six percent of nosocomial pneumonias are associated with mechanical ventilation and are termed ventilator- associated pneumonia (VAP). Ventilator-associated pneumonia is defined as pneumonia occurring more than 48 h after patients have been intubated and received mechanical ventilation. Diagnosing VAP requires a high clinical suspicion combined with bedside examination, radiographic examination, and microbiologic analysis of respiratory secretions.
to compare the Efficacy and nephrotoxicity of extended versus intermittent infusion of beta-lactams for the treatment of ventilator associated pneumonia.
This Retrospective cohort study has been held in Intensive Care Units in Ain Shams University Hospitals on critically ill patients with ventilator associated pneumonia after applying exclusion criteria, in the period from April 2023 till December 2023. After approval of Ethical & Research committee of Ain Shams University.
The current study results compared between the extended infusion group and the intermittent infusion group based on bacterial eradication, statistically significant differences were observed. In the extended infusion group, 70.0% of patients achieved bacterial eradication, whereas in the intermittent infusion…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 48 participants or records.
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