IDDF2018-ABS-0120 The effect of OMEGA-3 fatty acid supplementation on paediatric non-alcoholic fatty liver disease: a meta-analysis of randomised controlled trials
Abstract
Background Paediatric non-alcoholic fatty liver disease (NAFLD) is an obesity-related disease with growing prevalence worldwide. While current guidelines recommend lifestyle modification, omega-3 supplementation has been suggested as an emerging therapeutic option. Despite supporting evidence demonstrated among adult NAFLD patients, similar meta-analysis among the paediatric population is lacking. The present review aimed to evaluate the efficacy of omega-3 supplementation among children with NAFLD. Methods A systematic review of all randomised controlled trials (RCT) on NAFLD patients aged 18 or under was conducted using 16 multiple databases including Medline, EMBASE and Cochrane Central Register of Controlled Trials. PRISMA guideline was followed. The search was conducted by two independent reviewers, with discrepancies resolved by the third reviewer. Outcomes were categorised into anthropometric (e.g. body mass index), cardio-metabolic (e.g. triglycerides and insulin resistance) and hepatic outcomes (e.g. liver enzymes). Using mean differences (MD), meta-analysis was conducted on outcomes reported in more than one study using a random-effect model. If only median and inter-quartile ranges were provided, they were transformed into mean and standard deviation before meta-analysis. Heterogeneity was examined using I2 statistics. The Cochrane Collaboration’s tool for assessing the risk of bias was used to examine the quality of the included studies. Results After screening…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 326 participants or records.
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