Effectiveness of omega-3 fatty acid supplementation in patients with Alzheimer disease: A systematic review and meta-analysis
Abstract
Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction. We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD. To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD. We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar. Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method. There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in AD patients in the short and medium term. La enfermedad de Alzheimer (EA) es una patología neurodegenerativa caracterizada por demencia de carácter progresivo asociada a una perdida global de funciones cognitivas. Se realizó una síntesis de evidencia a través de una revisión sistemática con metaanálisis de ensayos clínicos que hayan evaluado la suplementación de omega-3 en pacientes con EA. Determinar si existe evidencia científica que avale la efectividad de la suplementación omega-3 en la mejoría de la función cognitiva de pacientes con EA. La estrategia de búsqueda incluyó solo ensayos clínicos aleatorizados (ECA). Las bases de datos usadas fueron: Medline,…
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