Polyunsaturated Fatty Acids and Diabetic Kidney Disease: What have We Learned so Far?
Abstract
Purpose of review: Despite various renoprotective agents, diabetic kidney disease (DKD) still progresses in some patients necessitating further novel therapeutic options. With regard to diet and healthy eating patterns, one dietary intervention for DKD is polyunsaturated fatty acids (PUFAs) supplementation yet the full scope of these this intervention is incompletely understood. In this narrative review, we summarized the literature (both experimental and clinical studies) specifically investigating the relationship between omega fatty acids and DKD. Additionally, we explored the potential molecular effects of omega fatty acids in DKD, identify knowledge gaps and put proposals for future studies.
Recent findings: PUFAs supplementation decreased blood pressure, total cholesterol, low density lipoprotein cholesterol, triglyceride levels, proteinuria/albuminuria and kidney injury and inflammatory markers. Furthermore, structural alterations such as tubulointerstitial fibrosis, mesangial expansion, capillary and tubular dilatation, podocyte foot process effacement, glomerular basal membrane thickening are reduced by PUFAs although some studies showed neutral effects. PUFAs supplementation is a feasible option for DKD although studies are heterogeneous but no safety signals raised. More studies are needed to understand robust relationship between PUFAs supplementation and DKD.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.