Association of omega-3/6 polyunsaturated fatty acids with three cerebrovascular diseases: A Mendelian randomization study
Abstract
Nutritional and dietary interventions are important in the prevention of stroke, but many of the factors influencing stroke remain undefined. Although omega-3/6 polyunsaturated fatty acids (PUFAs) have been suggested to be associated with cerebrovascular diseases, studies on this topic are lacking. This study extracted and screened independent single nucleotide polymorphisms of omega-3/6 PUFAs and 3 types of cerebrovascular diseases data from the IEU Open GWAS database. A two-sample Mendelian randomization (MR) was used to examine the association between omega-3/6 PUFAs with subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and ischemic stroke (IS). The primary analysis method was the inverse variance weighting method, supplemented by the weighted median and MR-Egger methods. Sensitivity and multiplicity were assessed using Cochran Q test, MR-PRESSO, MR-Egger regression, and leave-one-out analysis. This study was conducted in full compliance with the STROBE guidelines throughout. The inverse variance weighting analysis revealed a negative correlation between omega-3 PUFAs and SAH (P = .0078). However, there was no correlation between omega-3 PUFAs and ICH (P = .3930) and IS (P = .2922). Additionally, there was no association between omega-6 PUFAs and SAH (P = .1399), ICH (P = .1399, 0.0660), and IS (P = .8571) using all 3 analytical methods. No heterogeneity or horizontal pleiotropy was observed. The study suggested that omega-3 PUFAs had a significant…
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.