Efficacy of Nutritional Interventions in Adult Poststroke Rehabilitation: Protocol for a Systematic Review and Trial Sequential Meta-Analysis
Abstract
Background: Malnutrition is a prevalent and serious concern in adult survivors of stroke, often worsening their clinical status and leading to a poor prognosis. However, the effectiveness of nutritional interventions in this population remains uncertain. Furthermore, the impact of nutritional support on functional recovery, especially in relation to rehabilitation outcomes, has not been sufficiently investigated.
Objective: This meta-analysis aims to synthesize evidence from existing randomized controlled trials (RCTs) to determine whether nutrient supplements confer measurable benefits in poststroke rehabilitation, with overall mortality as the primary outcome and multiple relevant indicators as secondary outcomes.
Methods: RCTs that compare nutrient supplements and a standard diet or placebo supplements in adult survivors of stroke will be included. Literature searches will be conducted in the PubMed, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang, and Cochrane Library databases. Two reviewers will independently perform the processes of literature retrieval, screening, data extraction, and assessment of risk of bias. Risk of bias in included studies will be evaluated using the revised Cochrane risk-of-bias tool for RCTs. Review Manager will be used for data pooling. Subgroup analysis, trial sequential analysis, and sensitivity analysis will be conducted.
Results: This study was funded in 2023 (2023ZDFC0301) and registered in PROSPERO…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.