Effect of modification in cell membrane fatty acid composition on adrenergic cardiac and vascular reactivity
Abstract
The work is dedicated to examination of the effect an omega-3 polyunsaturated fatty acids (PUFA) on vascular and cardiac reactivity in intact animals. In experiments on isolated perfused rat hearts and isolated rings of rat aorta it was shown that reactivity in rats with modified membranes was lesser than in control animals after adding norepinephrine in raising concentrations. Use of omega-3 PUFA resulted in the decrease of omega-6 PUFAs (arachidonic acid (AA)) content, while omega-3 PUFAs (EPA, DHA) content in cardiomyocytes membranes increased. Besides that it was shown that after omega-3 PUFA enriched diet NO3- content increased in cardiac tissues and blood.
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