The effects of dietary omega-3 polyunsaturated fatty acid supplementation on attention and impulsivity in an animal model of attention deficit/hyperactivity disorder (ADHD)
Abstract
Background: Attention deficit/hyperactivity disorder (ADHD) is one of the commonest psychiatric disorders in children and adolescents. The main symptoms of ADHD are hyperactivity, inattention and impulsivity. Both etiology and neurobiological basis of ADHD are unknown. In this context, long-chain polyunsaturated fatty acids (LC-PUFAs), especially omega-3 (n-3) PUFAs, have become a focus of interest. The symptoms of ADHD have been suggested to be associated with a deficiency of n-3 PUFAs. In addition, the impact of a supply of dietary n-3 PUFAs in the treatment of ADHD has frequently been discussed. Objective: The aim of the present study was to examine the influence of n-3 PUFA supplementation on attention and impulsivity in the spontaneously hypertensive rat (SHR) which has been proposed to be a valid genetic animal model of ADHD. Methods: Seven-week-old male SHRs were randomly divided into two groups of 15 rats and fed one of two experimental diets (n-3 PUFA-enriched or n-3 PUFA-deficient) prior to and during behavioral testing. Attention and impulsivity were assessed using a three-choice-serial-reaction-time-task (3CSRTT) which is based on the five-choice-serial-reaction-time-task. The experiment was performed with three-month-old rats. Results: Our findings demonstrate a marked difference between groups regarding impulsivity but not attention. The n-3 PUFA-enriched diet significantly reduced impulsivity in SHRs compared with rats fed with the n-3 PUFA-deficient diet.…
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