In vivo monitoring of hepatic glycolipid distribution of n-6 ∕ n-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal
Abstract
Abstract The metabolic distribution via blood from liver of glycerolipids by omega-6 to omega-3 fatty acid (n-6 / n-3) ratio in monogastric animal nutrition is very important. In vivo monitoring technique using jugular-vein-cannulated rats as a nutritional model for monogastric animal can yield important insights into animal nutrition. This study was conducted to determine the effect of different n-6 / n-3 ratios (71:1, 4:1, 15:1, 30:1) on metabolic distribution of glycerolipids newly synthesized and secreted in the liver of the rats and explore the mechanism involved. Regarding 14CO2 released from oxidation of glycerolipid metabolism, it was the highest (22.5 %) in groups with a n-6 / n-3 ratio of 4:1 (P<0.05). The control group showed the highest total glycerolipid level, followed by the 30:1, 15:1, and 4:1 groups in order (P<0.05). When secreted triacylglycerol level of each group was compared with that of the control group, the 4:1, 15:1, and 30:1 groups were decreased by 36.3 %, 20.9 %, and 13.3 %, respectively (P<0.05). Regarding the distribution of phospholipid against total glycerolipid compared to the control group, the 4:1, 15:1, and 30:1 groups were 1.38, 1.29, and 1.17 times higher, respectively (P<0.05). In the comparison of 14CO2 emission against total glycerolipid compared with the control group, the 4:1, 15:1, and 30:1 groups were 1.61, 1.52, and 1.29 times higher, respectively (P<0.05). These results demonstrate that a dietary n-6 / n-3 fatty acid ratio of…
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.