Tocilizumab in severe COVID-19 pneumonia: A retrospective case-control study from eastern India
Abstract
Coronavirus disease 2019 (COVID-19) is associated with a dysregulated immune response leading to a hyperinflammatory state, termed cytokine storm.[1-3] The disease severity depends on macrophage activation, which releases proinflammatory cytokines, subsequently causing an exaggerated host immune response leading to organ dysfunction.[4,5] Administering interleukin-6 (IL-6) receptor antagonists may reduce the progression of disease severity associated with COVID-19 pneumonia.[6] Recent trials have shown equivocal results in the drug’s efficacy concerning patient outcomes.[2,3,6] This prompted us to conduct a retrospective case–control study to evaluate the impact of tocilizumab on patients suffering from COVID-19. We present the following research in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting checklist.
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
Read the paper
Related studies
- Penicillins for Treatment of Pneumococcal Pneumonia: Does In Vitro Resistance Really Matter?
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.