Boswellia carterii Essential Oil and Constituents Alleviate Anxiety-like Behavior in Zebrafish Larvae Model
Abstract
Herbal medicines are increasingly recognized as alternative therapies for anxiety. Boswellia species are traditionally used in East Africa to manage central nervous system disorders. In the present study, Boswellia carterii, its major compound α-pinene, and the enantiomers (-)-α-pinene and (+)-α-pinene were investigated for potential anxiolytic activity using an in vivo zebrafish larvae model. Chiral analysis using Gas Chromatography-Time-of-Flight Mass Spectrometry confirmed α-pinene as a scalemic mixture of (-)-α-pinene and (+)-α-pinene in B. carterii essential oil. In behavioral assays, B. carterii essential oil exhibited significant anxiolytic activity at 50 and 100 μL/L (p p in vivo (p in vivo anxiolytic-like effects were not distinctly enantioselective. The stereochemistry did, however, affect the predicted binding orientation in the active site and in-silico ligand-receptor interactions, supporting further investigation of the α-pinene enantiomers as lead compounds with activity at the CB2 receptor.
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