In silico Target Class Prediction and Probabilities for Plant Derived Omega 3 Fatty Acid from Ethyl Acetate Fraction of Moringa oleifera Leaf Extract
Abstract
Plant Derived Omega 3 Fatty Acid – α Linolenic Acid (ALA) a carboxylic acid with 18 carbon atoms, 3 cis double bonds. ALA obtained from plant based food source is converted into eicosa-pentaenoic acid (EPA) and docosa-hexaenoic acid (DHA). However, the rate of conversion is influenced by dose, gender, and health status. Further, intake of ALA significantly reduces the risk of sudden death among myocardial infarction patients consistent with induced antiarrhythmic effect. ALA is concomitant with cardiovascular-protective, anti-cancer, neuro-protective, anti-osteoporotic, anti-inflammatory, and anti-oxidative properties. ALA has anti-metabolic syndrome that regulates gut-micro-floral functionalities. Clinical trials indicate that ALA can be used in the management of multi-metabolic syndrome effects but in-depth target based ADMET studies are required to ascertain its clinical efficacy and market potential.
Keywords: ADMET; Moringa oleifera; Secondary Metabolites; Natural Products (NPs); Bioactive Substances; Octadecatrienoic acid (ODA); Eicosa-Pentaenoic Acid (EPA); Docosa-Hexaenoic Acid (DHA); Plant Derived Omega 3 Fatty Acid (PDO3FA)
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