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Exploring how older adults perceived the impact of infectious diseases and vaccines on ageing: a cross-sectional study in France

Alexandra Addario, G. Gavazzi, T. Celarier, B. Chapoton, N. Barth, B. Bongué, E. Botelho-Nevers

BMC Geriatrics, 2026

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Abstract

This cross-sectional study examined perceptions of health and ageing, and their influence on vaccine acceptance among individuals aged 65 and older living at home in the Auvergne-Rhône-Alpes region of France. Anonymous online questionnaires were distributed to users of CARSAT Rhône-Alpes (N1 = 50,000) and Auvergne (N2 = 9,597). The 62-question survey covered vaccination perceptions, the impact of the Covid-19 pandemic, health concerns, preventive measures, health information sources, and vaccination history. Vaccine hesitancy was assessed using the 5 C model, categorizing respondents into the group ‘Opposed’, ‘Hesitant’, and ‘Very Favourable’ to vaccination based on vaccination history and reasons for non-vaccination. Out of 3,331 respondents, 2,416 questionnaires were analysable. Most participants identified stroke (43.4%), cancer (20.4%), and dementia (18%) as primary health concerns. Infectious diseases ranked lowest, with pneumonia (1.24%), Covid-19 (0.89%), influenza (0.43%), and shingles (0.11%) infrequently cited. The Hesitant group more frequently questioned vaccination recommendations (82%) compared to the Very Favourable group (74%). Opposed participants significantly doubted vaccine efficacy and its role in healthy aging, differing from Hesitant and Very Favourable participants (p < 0.001). Perceptions of vulnerability to infection and beliefs about the seriousness of vaccine-preventable diseases significantly differed among groups (p < 0.001), with higher…

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