Hospital-based antibiogram profile and resistance patterns of gram-negative pathogens cross-sectional study from Sudan
Abstract
Background: This retrospective cross-sectional study evaluated the antibiogram profile of Gram-negative bacterial infections at Yastebsheron Hospital. The study aimed to identify prevalent pathogens, assess antimicrobial susceptibility patterns, and develop evidence-based recommendations for empirical antibiotic therapy. Methods: A total of 1,182 clinical specimens (urine, swabs, aspirates, and cerebrospinal fluid) collected in 2022 were analyzed following standard microbiological procedures. Culture and sensitivity testing were performed according to established protocols. Data were analyzed using SPSS version 23 and Microsoft Excel, with results presented through descriptive statistics. Results: Gram-negative bacteria accounted for 48.4% of isolates. Urinary tract infections (UTIs) were the most prevalent, with a significantly higher incidence among female patients (67%). Escherichia coli (59.8%) was the predominant uropathogen. Among the frequently isolated pathogens E. coli (52.5%), Enterobacter spp . (21.9%), Proteus mirabilis (9.8%), and Pseudomonas aeruginosa (8.4%) meropenem demonstrated the highest efficacy. Levofloxacin showed excellent activity against Enterobacter spp . and P. mirabilis (92% susceptibility), while amikacin exhibited moderate effectiveness against E. coli (78%). Morganella morganii displayed the highest multidrug-resistance rates. Colistin was universally effective against P. aeruginosa. Third-generation cephalosporins and nalidixic acid showed…
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Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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