Efficacy of Antibiotics Against Pseudomonas aeruginosa Isolated from Respiratory Devices in Tanzania
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen responsible for severe hospital-acquired infections, including ventilator-associated pneumonia. Due to its biofilm-forming ability and antimicrobial resistance, it presents a significant public health challenge. This study assessed the efficacy of selected antibiotics against P. aeruginosa isolates associated with respiratory devices from regional referral hospitals in mainland Tanzania. A cross-sectional study was conducted in 2024, in which samples were collected from January to March in Emergency wards, Intensive care units, and Medical wards. Samples collected included water from the Oxygen humidification container, swab samples from reusable masks and the connectors. Laboratory analysis using standard microbiological techniques and PCR were employed for isolation and confirmation of P. aeruginosa. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disc diffusion method. Out of the collected samples (N=231), P. aeruginosa was detected at an overall prevalence of 14.7% (n=34). The analysis of prevalence by sample type revealed that water for humidification had the highest prevalence of 30.6%, followed by respirators at 8.2% and the least in connectors at 3.5%. P. aeruginosa showed a notable resistance towards gentamycin, followed by meropenem, and the least resistance was shown in ceftazidime. On the other hand, P. aeruginosa were fully susceptible to piperacillin-tazobactam combination. A very…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 231 participants or records.
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