Comparative Efficacy of 5% Dextrose and Corticosteroid Injections in Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis
Abstract
OBJECTIVE
This study aims to assess the effectiveness of 5% dextrose (D5W) in comparison to corticosteroids for treating carpal tunnel syndrome (CTS).
DATA SOURCES
A comprehensive systematic search was conducted across MEDLINE (PubMed), Embase, and the Cochrane Central Register of Controlled Trials on November 13, 2023. These were supplemented by manual searches using Google Scholar.
STUDY SELECTION
Two independent authors reviewed the literature, resolving any discrepancies through detailed discussions and consultation with a third author.
DATA EXTRACTION
Data on primary outcomes (pain assessment) and secondary outcomes (symptom severity and functional status using the Boston Carpal Tunnel Questionnaire, electrophysiologic measures, cross-sectional area, and adverse effects) were extracted independently by the two authors.
DATA SYNTHESIS
The analysis included 4 randomized controlled trials and 1 quasi-experimental study, encompassing a total of 212 patients (220 hands) with mild to moderate CTS.
RESULTS
Within 3 months, the D5W injections showed a statistically significant improvement in functional status compared to the corticosteroids with a standard mean difference of -0.34 (95% confidence interval (CI), -0.62 to -0.05). D5W was associated with fewer adverse incidents than corticosteroids (risk ratio 0.13; 95% CI 0.03 to 0.51). No difference was observed between the two treatments in other areas.
CONCLUSION
For patients with mild to moderate CTS, D5W injections were more…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 212 participants or records.
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