Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: A systematic review and meta-analysis
Abstract
Background: Medicinal cannabinoids, including medicinal cannabis, pharmaceutical cannabinoids and their synthetic derivatives, including tetrahydrocannabinol (THC) and or cannabidiol (CBD), have been suggested to have a therapeutic role for certain mental health conditions. The primary objective was to review the evidence for cannabinoids in treating symptoms of depression, anxiety, post-traumatic stress disorder, attention-deficit hyperactivity disorder, Tic/Tourette syndrome, and psychosis, either as the primary condition or secondary to other conditions. Secondary outcomes included quality of life and global functioning. Methods: We undertook a systematic review and meta-analysis of published and unpublished studies (1980-2018) using MEDLINE, Embase, PsycINFO, and Cochrane Central Register of Controlled Clinical Trials, clinicaltrials.gov, the EU Clinical Trials Register, and the Australian and New Zealand Clinical Trials Registry. We included randomised controlled trials (RCTs) and non-RCT treatment studies. Two independent reviewers screened all studies and performed data extraction. RCT evidence was synthesised, as odds ratios (ORs) for disorder remission and standardised mean differences (SMDs) for change in symptoms, via random-effects meta-analyses. Evidence quality was evaluated using the Cochrane Risk of Bias and GRADE approaches. Findings: A total of k=83 studies (k=40 RCTs, n=3067) were included: k=40 for depression (k=22 RCTs, n=2524), k=31 for anxiety (k=17…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 3,067 participants or records.
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