Effects of mosquito control using the microbial agent Bacillus thuringiensis israelensis (Bti) on aquatic and terrestrial ecosystems: a systematic review
Abstract
Background: The bacterium Bacillus thuringiensis serovar israelensis (Bti) is commercially produced in various formulations for use as a larvicide worldwide, targeting especially the aquatic larval stage of mosquitoes. However, there is a concern that repeated Bti treatments may have both direct and indirect impacts on non-target organisms (NTOs) and the ecosystems they inhabit. This review evaluates the evidence for such impacts.
Methods: Literature was searched using six bibliographic databases, two search engines, and on specialist web sites. Eligibility screening was performed in two steps on (1) title/abstract, with consistency among reviewers assessed by double-screening 557 articles and (2) full text. Articles included after full text screening were critically appraised independently by two reviewers. Disagreements were reconciled through discussions. Key parameters of included studies are presented in narrative synthesis tables, including risk of bias assessments. Meta-analyses comparing treated with untreated ecosystems and using either the raw mean difference or log response ratio as effect size were performed.
Review findings: Ninety-five articles covering 282 case studies were included in the review. From these, we identified 119 different response variables, which were divided into nine outcome categories. Most studies investigated NTO abundance or life history (reproduction related outcomes), but diversity and community composition are also well represented as…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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