Effect of shorter silicone oil tamponade time on visual function recovery and associated factors in patients with rhegmatogenous retinal detachment
Abstract
BACKGROUND: There were no standardized clinical criteria for the duration of silicone oil (SO) tamponade for rhegmatogenous retinal detachment (RRD). This study aimed to investigate the effect of shorter SO tamponade time on visual function recovery in patients treated with a 2-month SO tamponade (Group A) compared to a 4-month SO tamponade (Group B) for RRD. METHODS: This is a prospective randomized controlled study. A total of 67 patients were included, 34 in Group A, and 33 in Group B. Best corrected visual acuity (BCVA), complications, inflammatory cytokine in aqueous humor, electrolyte levels, choroidal vascularity index (CVI), and choroidal thickness (CT) were measured at the timing of 1 week before SO removal (before SOR) and 3 months after SOR (after SOR). RESULTS: After SOR, Group A showed better BCVA (P = 0.002), lower SO emulsification rate (P < 0.001), and lower level of IL-1β than Group B (P = 0.016); other inflammatory factors were not statistically significant between the two groups. BCVA after SOR was better than before SOR in Group A (P < 0.001). Group B CVI before SOR was lower than after SOR (P = 0.013). When the two groups were analyzed together, BCVA after SOR was significantly improved compared with that before SOR (P < 0.001), and CVI after SOR was also significantly higher (P = 0.021); the difference in the electrolytes, CT, and CVI between the two groups was not statistically significant. CONCLUSIONS: A 2-month SO tamponade compared with a 4-month SO…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 67 participants or records.
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.