Association between admission serum hemoglobin concentration and the Black Hole Sign on cranial CT in ICH patients: A cross-sectional study
Abstract
OBJECTIVE
This study explores the correlation between admission hemoglobin (HGB) concentration and the Black Hole Sign (BHS) presence on cranial CT scans in spontaneous intracerebral hemorrhage (ICH) patients. Given the prognostic value of BHS in predicting early hematoma expansion and the potential role of HGB levels in influencing outcomes in cerebrovascular conditions, this study seeks to explore the correlation between these two factors. By analyzing clinical and imaging data from the past five years, we aim to provide new insights into the relationship between HGB concentrations and BHS in ICH patients.
METHODS
A single-center cross-sectional study gathered data from 330 ICH patients admitted to Chongqing Emergency Medical Center's neurosurgery department between June 2018 and November 2023. Logistic regression and subgroup analysis analyzed the association between admission HGB concentration and BHS occurrence. Curve fitting evaluated any linear relationship.
RESULTS
Among 330 patients (mean age: 58.4 ± 13.1 years, 72.1 % males), 40.0 % exhibited BHS on initial CT scans. Multifactorial adjustments revealed a negative correlation between admission HGB concentration and BHS. In subgroup analyses of age, sex, volume of cerebral hemorrhage, insular leaf damage, cerebral hernia, thalamic hemorrhage, and ventricular hemorrhage, No significant interactions were observed between subgroups. For every 1 g/L rise in HGB upon admission, there was a 3 % reduction in BHS likelihood…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 330 participants or records.
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