Disparities in supportive care breast cancer clinical trial enrollment
Abstract
e13786
Background:
Supportive care clinical trials (CTs) are crucial for improving breast cancer (BC) survivorship, yet the representation of diverse demographic groups is insufficiently characterized.
Methods:
We conducted a systematic review of supportive care BC CTs registered on ClinicalTrials.gov with enrollment in the United States from 1/2010 to 9/2022. We excluded CTs that limited enrollment to specific demographic groups. One-sample proportion tests were used to assess racial, ethnic, and age representation across trials and by intervention and funding type using incidence data from the SEER registry.
Results:
A search of 2695 CTs identified 173 supportive care BC CTs. Of these, 128 (74%) reported race data, 99 (57%) reported ethnicity data, and 30 (17%) reported age data and were included. Demographic data across trials overall and by intervention and funding type are summarized in the table. Black (10.5% vs 11.6%, p 65; 26.4% vs 44.4%, p < 0.001) were underrepresented across CTs overall. Asian, Hispanic, and older adults were underrepresented across all intervention subtypes and academic trials (p < 0.001). Hispanic and older adults were least represented in sexual health CTs. Black, Hispanic, and older adults were underrepresented in industry trials (p < 0.001).
Conclusions:
Black, Asian, Hispanic, and older adults are underrepresented in supportive care BC CTs, with adequate representation in only a minority of CT intervention/funding subtypes. Enhancing CT…
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