Post Hoc Analyses of DKD Clinical Trials in Ethnic Minorities (Asian, Hispanic, Black) Narrative Review
Abstract
PURPOSE
The burden of Diabetic kidney disease (DKD) is escalating, with a particularly adverse impact on ethnic minority populations. Clinical trials of nonsteroidal mineralocorticoid receptor antagonist (nsMRA), such as finerenone, Sodium-Glucose Transport Protein 2 Inhibitors (SGLT2i), and Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been conducted to minimize the DKD burden. The results and adequate representation of racial and ethnic minority groups in those clinical trials need special focus.
METHODS
A narrative review approach was utilized, using PubMed and Google Scholar Search tools for clinical trials of finerenone and different SGLT2i in patients with DKD. Subgroup analyses based on race, ethnicity, and geographic regions were extracted from the original manuscripts of each clinical trial and its supplement. Ethnic representation was also identified from published clinical trial results on ClinicalTrials.gov. The literature review also included Post hoc analysis of those clinical trials that study the effect of these medications on different races, ethnic minorities, and geographic regions.
FINDINGS
Post hoc analysis of clinical trials on finerenone and SGLT2i found no significant differences in the primary composite cardiorenal outcome by race/ethnicity, suggesting consistent efficacy of these medications across diverse populations. Furthermore, the overall incidence of serious adverse events or adverse events of interest in these analyses were…
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.