A randomized clinical trial comparing low-fat versus precision nutrition-based diets for weight loss: impact on glycemic variability and HbA1c
Abstract
BACKGROUND
Recent studies have demonstrated considerable inter-individual variability in postprandial glucose response (PPGR) to the same foods (1), suggesting the need for more precise methods for predicting and controlling PPGR. In the Personal Nutrition Project, the investigators tested a precision nutrition algorithm for predicting an individual's PPGR.
OBJECTIVE
To compare changes in glycemic variability (GV) and HbA1c in two calorie-restricted weight loss diets in adults with prediabetes or moderately-controlled type 2 diabetes (T2D), which were tertiary outcomes of the Personal Diet Study.
RESEARCH DESIGN
The Personal Diet Study was a randomized clinical trial to compare a one-size-fits-all low-fat diet (hereafter, Standardized) versus a personalized diet (hereafter, Personalized). Both groups received behavioral weight loss counseling and were instructed to self-monitor diets using a smartphone app. Personalized received personalized feedback via the app to reduce their PPGR. Continuous glucose monitoring (CGM) data were collected at baseline, 3- and 6-months. Changes in mean amplitude of glycemic excursions (MAGE) and HbA1c at 6 months were assessed. We performed intention-to-treat analysis using linear mixed regressions.
RESULTS
We included 156 participants (66.5% female, 55.7% White, 24.1% Black, mean age 59.1 years (SD=10.7)) in these analyses (Standardized = 75, Personalized = 81). MAGE decreased by 0.83 mg/dL per month for Standardized (95% CI: 0.21, 1.46…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 156 participants or records.
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.