Investigating reasons patients do not join a cancer clinical trial
Abstract
11092
Background:
The perennial challenge to cancer clinical trials is accrual. To date, the focus to improve accruals rested on addressing patient knowledge, attitudes and beliefs rooted in patient reluctance to be experimented on, financial and practical barriers and issues of mistrust. We undertook this study to describe the impact of an educational intervention to democratize recruitment and improve understanding of and information about cancer clinical trials.
Methods:
We implemented a time series intervention (INT) identifying cancer patients at treatment decision points at 3 participating Cancer Centers, educating consented breast, liver and lung cancer patients about clinical trials in general and providing clinical trial match lists to oncologists and patients prior to treatment decision-making. We defined a treatment decision point as a new, recurrent or progressing cancer. We surveyed patients and their oncologists pre- and post-intervention about their knowledge, attitudes and beliefs (KABs) of clinical trials. We compared pre & post KABs using Chi Sq and Fisher’s Exact T tests.
Results:
Of 523 consented patients at treatment decision points, 514 completed pre & 368, post-INT surveys; 60% were non-white with no racial ethnic difference in response rates (70% BIPOC v 79% White; p = 0.07). Following an educational intervention, there was no significant change in positive attitude towards clinical trials (CT): 71% pre-intervention vs 77% post-intervention; p = 0.55,…
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.