Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
Abstract
In early stages of Alzheimer's disease (AD), soluble amyloid-β (Aβ) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. Although the hippocampus has been a central focus in prior research because of its susceptibility to Aβ-induced alterations, a comprehensive understanding of the temporal progression of early AD pathology requires exploring interconnected brain regions. The posterior parietal cortex (PPC), collaborating closely with the hippocampus and involved in various memory processes, particularly spatial memory formation, holds particular significance. Investigating the function of the PPC is imperative because it may contribute to early AD characteristics and provide a more holistic perspective on disease progression. To address this gap, we examined the relationship between neural oscillations and memory processes in both the PPC and hippocampus, in a mouse model of early hippocampal amyloidosis generated by intracerebroventricular oligomeric Aβ1-42 (oAβ1-42) injection. By performing in vivo oscillatory activity recordings from these regions in alert animals, together with spatial and habituation memory tests (Barnes maze and open field habituation), we found oAβ1-42 to induce significant alterations in PPC oscillatory activity. These changes emerged several days after hippocampal disturbances showed as aberrant synaptic plasticity and network activity. Additionally, significant alterations of…
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