Risk of Glaucoma after Pars Plana Vitrectomy in a Large Federated Health Record Network
Abstract
Purpose: To examine the risk of glaucoma after pars plana vitrectomy (PPV).
Design: We conducted a retrospective cohort study using aggregate electronic health record data from the large, federated TriNetX network.
Subjects: We identified a retrospective cohort of 42 242 patients from 67 health care organizations in the United States who underwent PPV based on Current Procedural Terminology (CPT) codes from the period between January 1, 2013 and December 31, 2018 and identified subcohorts based on preoperative diagnoses of epiretinal membrane, macular hole, tractional retinal detachment, and rhegmatogenous retinal detachment.
Methods: Among these patients, we identified patients who were newly diagnosed with glaucoma after PPV based on International Classification of Diseases, Tenth Revision codes, those who required topical intraocular pressure (IOP)-lowering medications after PPV, and those who required incisional glaucoma surgery based on CPT codes, in the postoperative period between 3 months and 5 years after surgery.
Main outcome measures: Five-year cumulative risk of new diagnosis of glaucoma, of initiation of topical IOP-lowering medications, or of need for incisional glaucoma surgery (i.e., glaucoma drainage implant or trabeculectomy); Kaplan-Meier probability of being diagnosed with glaucoma or of requiring topical IOP-lowering medications.
Results: In our retrospective cohort, >5% of patients who underwent PPV were newly diagnosed with glaucoma and >9% newly…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 42 participants or records.
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