Outcome of sutureless amniotic membrane dressing ring for acute Stevens-Johnson syndrome with severe ocular involvement: A case report of 5 patients
Abstract
Rationale: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis can lead to severe ocular damage and long-term vision complications. Our self-made sutureless amniotic membrane dressing (AMD) ring leverages the anti-inflammatory and regenerative properties of the amniotic membrane (AM), promoting healing, reducing scarring, and enhancing patient comfort.
Patient concerns: Five consecutive patients (3 females, 2 males; aged from 18 to 53 years) with acute SJS/TEN were at immediate risk of significant ocular surface damage, including corneal and conjunctival epithelial defects and eyelid margin erosions, which can progress to chronic dry eye, scarring, or permanent vision loss without timely intervention.
Diagnoses: All patients were diagnosed with SJS/TEN based on their clinical presentations, including acute onset of mucocutaneous eruptions and extensive epidermal detachment, and comprehensive histories, confirmed by a dermatologist. Ocular involvement was assessed through detailed ophthalmologic examination and classified using the Sotozono grading system.
Interventions: A self-made AMD ring, inspired by commercially available products such as Prokera, was used to cover the ocular surface. Constructed from readily available materials, this ring provides therapeutic benefits similar to Prokera without the need for suturing.
Outcomes: High epithelial healing rates and stable follow-up visual acuity underscore this technique's potential efficacy in selected SJS/TEN…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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