HPA–SAM Co-Activation Among Racially Diverse, Economically Disadvantaged Early Adolescents: Secondary Analysis with a Preliminary Test of a Multisystem, Person-Centered Approach
Abstract
Investigating the co-activation of hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenomedullary (SAM) responses to acute stress can provide insight into how risk might become biologically embedded during early adolescence and improve understanding of what distinguishes physiological dysregulation from normative/expected physiological responses to stress. Evidence has thus far been mixed as to whether symmetric or asymmetric co-activation patterns are associated with higher exposure to chronic stress and poorer mental health outcomes during adolescence. This study expands on a prior multisystem, person-centered analysis of lower-risk, racially homogenous youth by focusing on HPA–SAM co-activation patterns in a higher-risk, racially diverse sample of early adolescents from low-income families (N=119, Mage=11.79 years, 55.5% female, 52.7% mono-racial Black). The present study was conducted by performing secondary analysis of data from the baseline assessment of an intervention efficacy trial. Participants and caregivers completed questionnaires; youth also completed the Trier Social Stress Test-Modified (TSST–M) and provided six saliva samples. Multitrajectory modeling (MTM) of salivary cortisol and alpha-amylase levels identified four HPA–SAM co-activation profiles. In accordance with the asymmetric-risk model, youth exhibiting Low HPA–High SAM (n=46) and High HPA–Low SAM (n=28) profiles experienced more stressful life events, posttraumatic stress, and emotional and…
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 119 participants or records.
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