65 Atropine for the treatment of paediatric sialorrhea: A retrospective case series
Abstract
Sialorrhea is a common problem among children with neurodevelopmental disorders, and can lead to significant complications, including aspiration pneumonia, skin breakdown, secondary infection, damaged dentition, and social challenges. Multiple medical options exist for the management of sialorrhea, but there is a paucity of data on efficacy and adverse effects in the paediatric population.
This single centre, retrospective chart review examined the efficacy of sublingual atropine drops in a paediatric population followed in a multidisciplinary sialorrhea clinic.
Patient demographics, comorbidities, clinical presentation, previous interventions, quality of life and medication side effects were collected. The Drooling Frequency and Severity Scale (DFSS) scores, collected during patient appointments, were reviewed to compare sialorrhea management pre- and post-treatment. A descriptive analysis was conducted to evaluate the efficacy of atropine. Wilcoxon signed rank tests were conducted to compare pre- versus post-treatment DFSS scores.
Between January 2015 and September 2023, 32 patients were treated with sublingual atropine; of these, 21 met inclusion criteria. The mean age of patients at initial presentation was 9.4 years. The majority of patients had neurodevelopmental disability and required assistive devices for ambulation. Twenty four percent of patients had previous trials of medication for sialorrhea, and 23.8% had previously trialled botox. The median DFSS score prior…
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