Morphea patients with mucocutaneous involvement: A cross sectional study from the Morphea in Adults and Children (MAC) cohort

S. Prasad, S. Black, Jane L. Zhu, Shivani Sharma, H. Jacobe

Journal of American Academy of Dermatology, 2020

735 participants · 14 citations

Abstract

BACKGROUND

Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized.

OBJECTIVE

To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions enrolled in the Morphea in Adults and Children Cohort (MAC).

METHODS

Cross-sectional study of 735 patients in the MAC Cohort from 2007 to 2018.

RESULTS

4.6% of linear morphea patients had oral involvement versus 2.4% among the entire cohort while 10.3% of generalized morphea patients had genital involvement versus 3.7% among the entire cohort. Those with genital lesions had an older age of disease onset than oral morphea (57 versus 11.5 years old; p<0.001) and more frequent extragenital lichen sclerosus atrophicus (LSA) (59.2% versus 5.6%; p=0.004).

LIMITATIONS

Selection bias and limited number of affected subjects.

CONCLUSION

Oral morphea lesions predominate in younger patients with facial linear morphea while genital lesions predominate in post-menopausal women with overlying extragenital LSA.

How strong is the evidence?

Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 735 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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