Efficacy of tilapia skin xenograft compared to paraffin-impregnated gauze as a full-thickness burn dressing after excisional debridement: A case series
Abstract
Introduction and importance Due to its high collagen, good adherence to wound bed, and great wound healing properties, Tilapia (Oreochromis niloticus) skin has been studied as a biomaterial in regenerative medicine, including as a burn dressing. This paper evaluated the efficacy of tilapia skin xenograft as a temporary full-thickness burn dressing. Methods Four acute burn patients aged 23–48 years old with total body surface area ranging from 27.5 to 37% with a similar burn area on both sides of the limbs were included. Each limb was dressed in tilapia skin or paraffin-impregnated gauze. Two subjects passed away due to septic shock. All limbs treated with tilapia skin xenograft required fewer dressing changes compared to the limbs treated with paraffin-impregnated gauze. All remaining subjects underwent skin autograft transplantation surgery on the eleventh day after the debridement surgery. No allergic reaction was found in any of the subjects. Outcomes The tilapia xenograft performed better in controlling and containing the exudates compared to the paraffin-impregnated gauze, as reflected in the fewer dressing changes needed. The cause of death of the two patients was questionable as both of them have severe pneumonia and COVID-19 still could not be ruled out yet. Conclusion The tilapia skin xenograft was not inferior to the standard paraffin-impregnated gauze for full-thickness burn dressing in terms of time needed for wound bed preparation for autograft surgery.
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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