Precut disc of lyophilized amniotic membrane for recurrent full thickness macular hole management
Abstract
Purpose: To assess the efficacy of precut disc of lyophilized amniotic membrane (LAM) in the management of recurrent full thickness macular hole (FTMH), already treated with pars plana vitrectomy (PPV), internal limiting membrane peeling, and gas tamponade.
Methods: Twenty-seven eyes of 27 patients with recurrent FTMH were included in this retrospective study and treated with 25G PPV, LAM graft (Visio Amtrix, TBF, Mions, France) and 20% SF6 gas tamponade. Spectral domain optical coherence tomography (SD-OCT) was used to assess anatomic FTMH closure 1 month postoperatively. Best corrected visual acuity (BCVA) was measured preoperatively and 1, 3, 6 and 12 months after surgery.
Results: Twelve eyes presented large idiopathic FTMHs, 12 showed large FTMH associated with high myopia and the remaining 3 had large FTMH and retinal detachment in highly myopic eyes. Mean minimum FTMH diameter at baseline was 782±341.17 μm and mean BCVA was 1.02±0.63 LogMAR. Postoperatively, anatomical FTMH closure was achieved in 23/27 (85.2%) eyes one month after the surgery. Mean BCVA progressively improved during the follow-up period, reaching 0.55±0.42 LogMAR (p = 0.04) at 12-months follow-up. No adverse events were registered during follow-up.
Conclusions: Results suggest that epiretinal graft of LAM precut discs is a safe and effective surgical procedure for large and recurrent FTMH treatment, leading to significant BCVA improvement.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 27 participants or records.
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.