Factors affecting targeting accuracy in minimally invasive twist drill deep brain stimulation
Abstract
Background: The efficacy of deep brain stimulation (DBS) relies on accurate stereotactic electrode placement. Post-implantation imaging enables assessment of electrode positioning and quantification of targeting accuracy. While DBS is typically performed through burr hole, this study examines targeting accuracy factors using a minimally invasive twist drill technique.
Methods: We retrospectively analyzed 86 patients (171 electrodes) who underwent DBS at our institution. Different measures of targeting error were defined and compared. Analysis focused on trajectory error (TE), the closest perpendicular distance between the electrode's center and target locus. Seventeen demographic, clinical, and procedural variables were assessed for potential impact on accuracy. Multivariate mixed effects models were applied to identify significant associations.
Results: Mean (±standard deviation) TE was 1.4 (0.7) mm. Electrodes tended to lie medial (0.3 ± 0.1 mm; mean ± 95% confidence interval), posterior (0.6 ± 0.1 mm), and superior (0.5 ± 0.1 mm) to targets. Three variables were independently and significantly associated with greater TE: use of one of two stereotactic frames (effect size 0.4 ± 0.2 mm), second-side implantation in bilateral surgery (0.3 ± 0.2 mm), and decreasing coronal approach angle (0.04 ± 0.03 mm/°). All three factors were associated with significantly more posterior implantation, while second-side and decreasing coronal angle also yielded a more superiorly located…
Read the paper
Related studies
- A Survey on Knowledge Graphs: Representation, Acquisition, and Applications
- Toxicity of nanomaterials
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies
- Halogen bonding (X‐bonding): A biological perspective
- Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
- Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.