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Changes in Neuropathic Pain Profiles by Dysesthesia-Matched Transcutaneous Electrical Nerve Stimulation: A Case Report

Hoei T, Nishi Y, Etoh S, Kawamura K, Shimodozono M

Cureus, 2025

Abstract

Transcutaneous electrical nerve stimulation (TENS) is widely used to treat neuropathic pain because of its safety, but its therapeutic efficacy is limited. Dysesthesia-matched TENS (DM-TENS) is an innovative intervention that synchronizes TENS parameters with an individual patient's perception of dysesthesia. This case report describes a patient with cervical spinal stenosis whose throbbing pain evolved into dysesthesia. DM-TENS was synchronized with each neuropathic pain profile. Initially, the patient's throbbing pain was rated 8 on a numerical rating scale (NRS), and the pinch force adjustment test (pinch test) showed a 2.58% mean error. DM-TENS synchronized to throbbing pain immediately reduced the NRS to 2 and the pinch test score to 2.06%. On postoperative day (POD) 13, the throbbing pain disappeared and evolved into dysesthesia (NRS 5, pinch test 2.41%). When the DM-TENS parameters were adjusted to match dysesthesia, immediate improvement was also achieved (NRS 0, pinch test 1.69%). By POD 20, the NRS for dysesthesia decreased to 3, and the patient reported high satisfaction. To our knowledge, this is the first case to demonstrate the effectiveness of DM-TENS synchronized with pain characteristics other than dysesthesia, highlighting the potential to broaden its clinical applications.

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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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