Individualized treatment for pediatric intracranial aneurysms in China: case series and literature review
Abstract
Objective: Pediatric intracranial aneurysms are rare, accounting for a small proportion of all aneurysms, yet they often present with acute onset, rapid deterioration, and a high risk of rupture. Diagnostic and therapeutic standards remain inconsistent due to limited evidence.
Methods: We retrospectively reviewed four pediatric patients (≤14 years) with ruptured intracranial aneurysms treated at our center from January 1, 2021 to December 31, 2025. Clinical presentation, imaging findings, treatment selection, and postoperative outcomes were analyzed. Functional outcomes were assessed using the modified Rankin Scale (mRS) over a 2-year follow-up period. And conduct a retrospective analysis based on literature to summarize the clinical presentation, treatment selection, prognosis, and other characteristics of pediatric intracranial aneurysms.
Results: All four pediatric patients successfully underwent either endovascular embolization or microsurgical clipping. Three patients achieved neurological improvement to varying degrees, while one patient with severe preoperative brain herniation died postoperatively. A total of 23 cases of pediatric intracranial aneurysms were retrieved from 21 English-language reports. Including the 4 cases in this study, the total number was 27. The male-to-female ratio was 16:11 (16 males and 11 females), and the age at onset ranged from 0.03 to 15 years (mean ± standard deviation: 6.5 ± 4.8 years). Clinical manifestations included sudden severe…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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